Hi all, Thanks for your replys and sorry for the delay in replying[computer probs]. Well since i last spoke to you all i have been diagnosed with anaemia so now im really tired[ha ha] I have been on the mtx now for 6 weeks,touch wood, the severe pain in my knees and shoulders have gone, only early days i know ,could return next week. I am already on hydroc-quine, steroids and mobic so it should be doing something, i rattle when i walk anyway. I noticed that quite a few of you were rheumatoid factor neg and because of this diagnosis was delayed, well i have always been rheumatoid factor positive, so it just goes to show. Well, speak to you all soon, take care, Jill